Automatic Verification of Message-Based Device Drivers

We develop a practical solution to the problem of automatic verification of the interface between device drivers and the OS. Our solution relies on a combination of improved driver architecture and verification tools. It supports drivers written in C and can be implemented in any existing OS, which sets it apart from previous proposals for verification-friendly drivers. Our Linux-based evaluation shows that this methodology amplifies the power of existing verification tools in detecting driver bugs, making it possible to verify properties beyond the reach of traditional techniques.Comment: In Proceedings SSV 2012, arXiv:1211.587

Multimodal retinal imaging: Improving accuracy and efficiency of image registration using Mutual Information

This thesis addresses the challenging task of multi-modal image registration. Registration is often required in a number of applications, whereby two images are aligned to give matching correspondence between the features in each image. Such techniques have become popular in many different fields, especially in medical imaging. Multi-modal registration would allow for anatomical structure to be studied concurrently in both modalities, providing the clinician with a greater insight of the patient's condition. Glaucoma is a serious condition that damages the optic nerve progressively, leading to irreversible blindness. The disease can be treated so to prevent any further infection, however it can not be reversed. Therefore it is paramount that the disease is detected in the early stages so to minimise the affect of the condition. The work in this thesis focuses on two particular imaging modalities: colour fundus photographs and scanning laser ophthalmoscope images. Both images are captured from the human eye and show the appearance and reflectivity of the retina respectively. Registration of these two modalities would significantly improve demarcation and monitoring of the optic nerve head, a crucial stage for glaucoma diagnosis. In recent years, Mutual Information has become a popular technique used to perform multi-modal registration. This thesis provides a comprehensive overview of the algorithm. Firstly, an investigation is performed that shows how probability estimation can improve the algorithm performance. Secondly, the weaknesses of the current technique are revealed and so a novel solution is proposed that overcomes these problems. Finally, the proposed solution is incorporated in a non-rigid registration scheme that provides excellent registration accuracy for our intended application

Measuring the intelligence of an idealized mechanical knowing agent

We define a notion of the intelligence level of an idealized mechanical knowing agent. This is motivated by efforts within artificial intelligence research to define real-number intelligence levels of compli- cated intelligent systems. Our agents are more idealized, which allows us to define a much simpler measure of intelligence level for them. In short, we define the intelligence level of a mechanical knowing agent to be the supremum of the computable ordinals that have codes the agent knows to be codes of computable ordinals. We prove that if one agent knows certain things about another agent, then the former necessarily has a higher intelligence level than the latter. This allows our intelligence no- tion to serve as a stepping stone to obtain results which, by themselves, are not stated in terms of our intelligence notion (results of potential in- terest even to readers totally skeptical that our notion correctly captures intelligence). As an application, we argue that these results comprise evidence against the possibility of intelligence explosion (that is, the no- tion that sufficiently intelligent machines will eventually be capable of designing even more intelligent machines, which can then design even more intelligent machines, and so on)

Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 Through 11 Years of Age with Cystic Fibrosis Heterozygous for F508del and a Minimal Function Mutation: A Phase 3b, Randomized, Placebo-controlled Study

Rationale: The triple-combination regimen elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) was shown to be safe and efficacious in children aged 6 through 11 years with cystic fibrosis and at least one F508del-CFTR allele in a phase 3, open-label, single-arm study. Objectives: To further evaluate the efficacy and safety of ELX/TEZ/IVA in children 6 through 11 years of age with cystic fibrosis heterozygous for F508del and a minimal function CFTR mutation (F/MF genotypes) in a randomized, double-blind, placebo-controlled phase 3b trial. Methods: Children were randomized to receive either ELX/TEZ/IVA (n = 60) or placebo (n = 61) during a 24-week treatment period. The dose of ELX/TEZ/IVA administered was based on weight at screening, with children <30 kg receiving ELX 100 mg once daily, TEZ 50 mg once daily, and IVA 75 mg every 12 hours, and children ⩾30 kg receiving ELX 200 mg once daily, TEZ 100 mg once daily, and IVA 150 mg every 12 hours (adult dose). Measurements and Main Results: The primary endpoint was absolute change in lung clearance index2.5 from baseline through Week 24. Children given ELX/TEZ/IVA had a mean decrease in lung clearance index2.5 of 2.29 units (95% confidence interval [CI], 1.97-2.60) compared with 0.02 units (95% CI, -0.29 to 0.34) in children given placebo (between-group treatment difference, -2.26 units; 95% CI, -2.71 to -1.81; P < 0.0001). ELX/TEZ/IVA treatment also led to improvements in the secondary endpoint of sweat chloride concentration (between-group treatment difference, -51.2 mmol/L; 95% CI, -55.3 to -47.1) and in the other endpoints of percent predicted FEV1 (between-group treatment difference, 11.0 percentage points; 95% CI, 6.9-15.1) and Cystic Fibrosis Questionnaire-Revised Respiratory domain score (between-group treatment difference, 5.5 points; 95% CI, 1.0-10.0) compared with placebo from baseline through Week 24. The most common adverse events in children receiving ELX/TEZ/IVA were headache and cough (30.0% and 23.3%, respectively); most adverse events were mild or moderate in severity. Conclusions: In this first randomized, controlled study of a cystic fibrosis transmembrane conductance regulator modulator conducted in children 6 through 11 years of age with F/MF genotypes, ELX/TEZ/IVA treatment led to significant improvements in lung function, as well as robust improvements in respiratory symptoms and cystic fibrosis transmembrane conductance regulator function. ELX/TEZ/IVA was generally safe and well tolerated in this pediatric population with no new safety findings. Keywords: children; cystic fibrosis; elexacaftor; ivacaftor; tezacaftor

Conferencing the international at the World Pacifist Meeting in India, 1949

This paper considers how the act of conferencing was central to imagining, negotiating and contesting post-war pacifism as an internationalist project. The paper contends that internationalism and the international conference are inexorably entwined. Through studying the conference geographers can explore the situated historical and political geographies of internationalism which belies its otherwise transcendent or universalist claims. A reading of the 1949 World Pacifist Meeting in India is used to make two key arguments. Firstly, it shows how conferences operate as stage-managed events through which to script and perform an alternative vision of internationalism. Half conference, half pilgrimage, the global composition of delegates was arranged to suggest a space ‘singularly free from any sense of geographical limitation’. Yet total immersion in the rich cultural and historical context of India marked an uneven internationalist arena, where the ‘Land of Gandhi’ was held with unparalleled revere. Secondly, whilst geographers and others have turned to conferencing in recent years, this has largely been contained to ‘summitry’ and high-end diplomacy. This paper calls for geographers to consider a wider range of conferencing spaces and practices, and argues that studying ‘other conferences’ by necessity opens up consideration of other forms of internationalism. The paper concludes that the World Pacifist Meeting’s delegates imagined an alternative form of internationalism, exemplified by an alternative form of international conference, which sought to challenge state-centric readings of global power relations

Rapid mixing and exchange of deep-ocean waters in an abyssal boundary current

The overturning circulation of the global ocean is critically shaped by deep-ocean mixing, which transforms cold waters sinking at high latitudes into warmer, shallower waters. The effectiveness of mixing in driving this transformation is jointly set by two factors: the intensity of turbulence near topography and the rate at which well-mixed boundary waters are exchanged with the stratified ocean interior. Here, we use innovative observations of a major branch of the overturning circulation—an abyssal boundary current in the Southern Ocean—to identify a previously undocumented mixing mechanism, by which deep-ocean waters are efficiently laundered through intensified near-boundary turbulence and boundary–interior exchange. The linchpin of the mechanism is the generation of submesoscale dynamical instabilities by the flow of deep-ocean waters along a steep topographic boundary. As the conditions conducive to this mode of mixing are common to many abyssal boundary currents, our findings highlight an imperative for its representation in models of oceanic overturning

The 3rd Reactive Synthesis Competition (SYNTCOMP 2016): Benchmarks, Participants & Results

We report on the benchmarks, participants and results of the third reactive synthesis competition(SYNTCOMP 2016). The benchmark library of SYNTCOMP 2016 has been extended to benchmarks in the new LTL-based temporal logic synthesis format (TLSF), and 2 new sets of benchmarks for the existing AIGER-based format for safety specifications. The participants of SYNTCOMP 2016 can be separated according to these two classes of specifications, and we give an overview of the 6 tools that entered the competition in the AIGER-based track, and the 3 participants that entered the TLSF-based track. We briefly describe the benchmark selection, evaluation scheme and the experimental setup of SYNTCOMP 2016. Finally, we present and analyze the results of our experimental evaluation, including a comparison to participants of previous competitions and a legacy tool.Comment: In Proceedings SYNT 2016, arXiv:1611.0717

Economic Evaluations of Occupational Health Interventions from a Company’s Perspective: A Systematic Review of Methods to Estimate the Cost of Health-Related Productivity Loss

Objectives: To investigate the methods used to estimate the indirect costs of health-related productivity in economic evaluations from a company’s perspective. Methods: The primary literature search was conducted in Medline and Embase. Supplemental searches were conducted in the Cochrane NHS Economic Evaluation Database, the National Institute for Occupational Safety and Health database, the Ryerson International Labour, Occupational Safety and Health Index database, scans of reference lists and researcher’s own literature database. Article selection was conducted independently by two researchers based on title, keywords, and abstract, and if needed, full text. Differences were resolved by a consensus procedure. Articles were selected based on seven criteria addressing study population, type of intervention, comparative intervention, outcome, costs, language and perspective, respectively. Characteristics of the measurement and valuation of health-related productivity were extracted and analyzed descriptively. Results: A total of 34 studies were included. Costs of health-related productivity were estimated using (a combination of) data related to sick leave, compensated sick leave, light or modified duty or work presenteeism. Data were collected from different sources (e.g. administrative databases, worker self-report, supervisors) and by different methods (e.g. questionnaires, interviews). Valuation varied in terms of reported time units, composition and source of the corresponding price weights, and whether additional elements, such as replacement costs, were included. Conclusions: Methods for measuring and valuing health-related productivity vary widely, hindering comparability of results and decision-making. We provide suggestions for improvement

Speciation, Luminescence, and Alkaline Fluorescence Quenching of 4-(2-methylbutyl)aminodipicolinic acid (H2MEBADPA)

4-(2-Methylbutyl)aminodipicolinic acid (H2MEBADPA) has been synthesized and fully characterized in terms of aqueous phase protonation constants (pKa\u27s) and photophysical measurements. The pKa\u27s were determined by spectrophotometric titrations, utilizing a fully sealed titration system. Photophysical measurements consisted of room temperature fluorescence and frozen solution phosphorescence as well as quantum yield determinations at various pH, which showed that only fully deprotonated MEBADPA2– is appreciably emissive. The fluorescence of MEBADPA2– has been determined to be quenched by hydroxide and methoxide anions, most likely through base-catalyzed excited-state tautomerism or proton transfer. This quenching phenomenon has been quantitatively explored through steady-state and time-resolved fluorescence measurements. Utilizing the determined pKas and quenching constants, the fluorescent intensity of MEBADPA2– has been successfully modeled as a function of pH